Elevator trim 1 division up.
Flaps 2 steps down (Press F7 twice).
Navigation lights on. Pitot heat on. Landing lights on. By night: Panel lights on.
Full throttle and RPM. Takeoff is easy at approx. 110 kts (123 mph).
When safely airborne reduce to 41" MAP and 2350 RPM. Let the aircraft accelerate
to 125-130 kts (138-145 mph) and climb, initially at 950 fpm. Maintain
a climb speed of 130-135 kts.
Reduce MAP to 35", 2350 RPM. Adjust climb rate to keep the speed around 125-135 kts.
MAP between 28" (economical cruise) and 32" (fast cruise), 2100 RPM. Reduce
RPM and/or throttle as fuel burns off to keep the speed constant.
Economical cruising speed is 165 kts true airspeed, or an indicated airspeed of
about 142 kts / 160 mph.
The service ceiling of the Short Sandringham was about 18000 ft, but if you carry passengers do not exceed 12000 ft. for more than 30 minutes at a time. The cabin is not pressurized.
Flight Simulator includes “runways” for flying boats in some parts of the world (particularly in the U.S.A.), but elsewhere you are on your own when landing. Reduce altitude to 1000 ft, and find a suitable place for landing against the wind. Taxi to the shore to let the passengers out. (Press SHIFT +E to open the doors, CTRL+SHIFT+F1 to shut the engines down)